Jose Mourinho will inevitably be the centre of attention as he takes charge of Tottenham for the first time this weekend while Manchester City look to get their Premier League title challenge back on track against Chelsea.
The former Chelsea and Manchester United manager has been charged with rescuing Spurs' season after this week's sacking of Mauricio Pochettino, with the club desperate to claw their way back into the top four.
At the top of the table, runaway leaders Liverpool have a winnable-looking fixture away to Crystal Palace but the chasing pack cannot afford to allow the gap to widen further.
City, licking their wounds after their 3-1 defeat by Liverpool earlier this month, host Frank Lampard's Chelsea, who are one point above them in the table, eight points behind Jurgen Klopp's side.
Leicester, in second place, ahead of Chelsea on goal difference, travel to England's south coast to take on Brighton.
Mourinho's first match in charge of Tottenham will be away to West Ham at the London Stadium on Saturday but he will not have the luxury of a honeymoon period.
The Portuguese boss has a number of issues to sort out, including addressing the woeful away form -- Spurs have not won on the road in the Premier League since January.
Last season's Champions League finalists have had a shocking start to the season, languishing in 14th place in the Premier League after just three wins in their opening 12 games.
With their new stadium to pay for, Tottenham are reliant on Champions League revenue but the outlook is not bright.
No team with as low a tally as Spurs have after 12 games -- 14 points -- has ever gone on to record a top-four finish.
Mourinho, often labelled a cheque-book manager, has made the right noises so far, saying at his first press conference he will not demand millions to spend in the transfer market.
"I don't need players, I am so happy with the players I have, I just need time to understand them better, to know everything about them," he said.
"My gift is this squad, the squad is very, very good."
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