Jose Mourinho faces tough test as he prepares Manchester United for a trip to Premier League leaders Liverpool while Manchester City look to get back into groove after last week's Chelsea defeat.
United have an impressive recent record against Liverpool, unbeaten in eight league games, but away fans will travel with a sense of trepidation to Anfield.
Unai Emery takes his Arsenal side, unbeaten in 21 matches in all competitions, to face struggling Southampton while Chelsea also travel to the south coast to take on Brighton.
Manchester City host seventh-placed Everton while Tottenham, fresh from reaching the Champions League knockout phase, face Burnley at Wembley.
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